Patented Technology

Technology Introduction

Genepharm Biotech Corp.

Patented Technology

Technology Introduction

Genepharm Biotech Corp.

Skin barrier regeneration and repair technology.

Patent number :US Patent 7300649 / TW Patent I352595

Skin is the largest organ of the human body, helping us to keep out external invasion and retain moisture internally. With environmental pollution, ageing, skin diseases and other internal and external factors, the skin’s self-regeneration mechanism is affected, resulting in various skin problems, such as roughness, wrinkles, aging, itching, and even skin diseases.

Genepharm uses its original Calcium-T technology platform to deliver calcium and five other mineral ions into the skin externally to maintain the balance of six trace elements and restore the gradient of calcium ions in the epidermis to a healthy “inverted trapezoid concentration distribution”. Restoring the skin’s self-regulation and repair mechanism, improve the water-locking function, and rebuild the skin’s barrier function from inside out.

The “inverted trapezoid concentration distribution” of calcium ions in the epidermis comes from the scientific literature, which proves that calcium ions effectively regulate the division and differentiation of skin cells. The epidermal cells, in the process of keratinization, form a complete skin barrier, which allows the skin’s stratum corneum to be built like a strong wall of bricks and clay to protect our bodies, enhancing water retention and contributing to the health of the skin. In abnormal or damaged skin, calcium ions are not usually arranged in an inverted trapezoid, and Calcium-T technology allows the calcium concentration of the skin to penetrate deep into the bottom layers of the epidermis, creating an inverted trapezoid structure that restores the skin’s normal skin regeneration and healthy barrier, solving skin problems at the root.

“Do you have skin problems?”

According to dermatological literature and international journals, abnormal calcium ion concentrations in the epidermis are associated with a variety of skin diseases. For example, patients with psoriasis, calcium ions in the epidermis are distributed in a circular pattern, and patients with dialysis, calcium ions in the epidermis are being distributed in a trapezoid pattern.

  • Intense dry and itchy skin

  • Abnormally sensitive skin

  • Chronic recurrent dermatitis

Atopic dermatitis is a type of allergic eczema that occurs in infants and children, but may also occur in adults.

One of the causes of atopic dermatitis is the loss of moisturizing function of the patient’s skin barrier, which makes it easy for allergens to invade the skin’s stratum corneum, resulting in symptoms such as itching, dryness, flaking, and red rash.

With our original Calcium-T technology platform, we can restore the calcium ions in the epidermis to a healthy “inverted trapezoid concentration distribution”, restore the skin’s self-regulatory repair function, and establish a healthy skin environment to effectively address the lack of skin barrier function in patients with atopic dermatitis, thereby relieving the discomfort of patients with atopic dermatitis.

“Complementary treatment of ectopic skin”

Atopic dermatitis causes very sensitive and dry skin, so patients can make more efforts in bathing, soaking and choosing cleansers in their daily life. Dermatologists recommend the use of clinically proven, hypoallergenic, soap-free and fragrance-free products for the treatment of atopic dermatitis. Our Skin barrier repairing series products also use the calcium ion repair technology of the skin, which is patented in Taiwan and the U.S. It has been clinically proven that a high concentration of calcium ions in the epidermis and a low basal concentration in the skin can promote cell division and differentiation to form a healthy skin barrier, resist allergens and free radicals, and prevent skin moisture loss.

Calcuim-T is a patented skin calcium infusion technology combined with marine calcium ion complex to repair the skin barrier and prevent dryness and sensitivity. Long-term use is effective in soothing the skin and restoring its protection.

Scientific Theory

Our skin needs calcium

alcium ion technology was published in 1999 in an internationally renowned dermatology book and has since revolutionized the concept of traditional skin care.

Since then, it has been published in international dermatology books and has been regarded as one of the most important dermatological theories of the 21st century.

Dry Skin and Moisturizer

  • Published in Chapter 6 of the second edition of the new 2006 Clinical and Basic Science in Dermatology series, Dry Skin and Moisturizer.Role of Calcium-T in the Regulation of Skin Barrier Homeostasis (2006) Tanojo H, Huang X, Maibach HI chapter6, Dry Skin and moisturizers, 2nd edition. moisturizers, 2nd edition.

Handbook of Cosmetic Science and Technology

  • In Chapter 16 of Handbook of Cosmetic Science and Technology, USA, 2009.Role of Calcium Ions in Regulation of Skin Barrier Homeostasis (2009) Tanojo H, Chang Y, Guo JW, Huang X, and Maibach HI chapter 16, Handbook of Cosmetic Science and Technology, 3rd edition.
  • In 2015, invited by Textbook of Cosmetic Dermatology, a French dermatology textbook, to write a chapter to promote the concept of skin barrier repair technology.

Topical Skin Solution Film Technology

Patent application number:

Gel-PAD (externally used film-forming sustained-release gel) obtained [Taiwan Patent 1561568] and [U.S. Patent 9918944]

Technical Description:

By combining two or more polymers to form a 3D molecular skeleton that can encapsulate the drug, the space inside the 3D molecular skeleton can be embedded with the active drug ingredients.

Technical Features:

Forms a colorless, transparent waterproof film (Pad) within 1-3 minutes of application on the skin. This film does not overflow, does not stick, does not stain clothing, and protects the topical medication inside the film, allowing the medication to remain on the skin for a longer period of time, increasing the medication’s ability to penetrate the skin for up to 13 days.

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